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<t>MetaCore</t> network analyses . The top 47 genes that matched to the probes that were differentially expressed between HER2+ and HER2- samples (p-values < 0.01 and log2-fold change > |1.0|) in the 24K panel are enriched with genes (marked by red cycles) belonging to two distinct regulatory networks. a . The first network includes genes (marked by red cycles) functionally connected to MYC ( c-Myc ). b . The second network is enriched by genes (marked by red cycles) centered around TP53 ( p53 ) and ESR1 . c . The 8 genes differentially expressed in both the 24K and 1.5K panels (marked by red cycles) are all connected in a network that includes TP53 (p53) , ESR1 , and MYC ( c-Myc ) d . Symbol legend. Abbreviations for gene names presented in Figure 5 are defined in Additional File , Tables S1-S3.
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ESR1 transcription targets regulated in CF. Network adapted from Genego <t>Metacore.</t> Grey lozenges indicate genes up-regulated in CF (including ESR1); white lozenges indicate genes down-regulated in CF. Arrows represent effect predicted by Metacore of ESR1 on gene, as shown on key. Gene names shown in bold are those whose direction of regulation in CF would be reinforced by ESR1, based on its predicted effect.
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MetaCore network analyses . The top 47 genes that matched to the probes that were differentially expressed between HER2+ and HER2- samples (p-values < 0.01 and log2-fold change > |1.0|) in the 24K panel are enriched with genes (marked by red cycles) belonging to two distinct regulatory networks. a . The first network includes genes (marked by red cycles) functionally connected to MYC ( c-Myc ). b . The second network is enriched by genes (marked by red cycles) centered around TP53 ( p53 ) and ESR1 . c . The 8 genes differentially expressed in both the 24K and 1.5K panels (marked by red cycles) are all connected in a network that includes TP53 (p53) , ESR1 , and MYC ( c-Myc ) d . Symbol legend. Abbreviations for gene names presented in Figure 5 are defined in Additional File , Tables S1-S3.

Journal: BMC Medical Genomics

Article Title: Expression profiling of formalin-fixed paraffin-embedded primary breast tumors using cancer-specific and whole genome gene panels on the DASL ® platform

doi: 10.1186/1755-8794-3-60

Figure Lengend Snippet: MetaCore network analyses . The top 47 genes that matched to the probes that were differentially expressed between HER2+ and HER2- samples (p-values < 0.01 and log2-fold change > |1.0|) in the 24K panel are enriched with genes (marked by red cycles) belonging to two distinct regulatory networks. a . The first network includes genes (marked by red cycles) functionally connected to MYC ( c-Myc ). b . The second network is enriched by genes (marked by red cycles) centered around TP53 ( p53 ) and ESR1 . c . The 8 genes differentially expressed in both the 24K and 1.5K panels (marked by red cycles) are all connected in a network that includes TP53 (p53) , ESR1 , and MYC ( c-Myc ) d . Symbol legend. Abbreviations for gene names presented in Figure 5 are defined in Additional File , Tables S1-S3.

Article Snippet: Network analyses were performed using MetaCore network building tools (GeneGo Inc., St. Joseph, MI).

Techniques:

ESR1 transcription targets regulated in CF. Network adapted from Genego Metacore. Grey lozenges indicate genes up-regulated in CF (including ESR1); white lozenges indicate genes down-regulated in CF. Arrows represent effect predicted by Metacore of ESR1 on gene, as shown on key. Gene names shown in bold are those whose direction of regulation in CF would be reinforced by ESR1, based on its predicted effect.

Journal: Respiratory Research

Article Title: Changes in transcriptome of native nasal epithelium expressing F508del-CFTR and intersecting data from comparable studies

doi: 10.1186/1465-9921-14-38

Figure Lengend Snippet: ESR1 transcription targets regulated in CF. Network adapted from Genego Metacore. Grey lozenges indicate genes up-regulated in CF (including ESR1); white lozenges indicate genes down-regulated in CF. Arrows represent effect predicted by Metacore of ESR1 on gene, as shown on key. Gene names shown in bold are those whose direction of regulation in CF would be reinforced by ESR1, based on its predicted effect.

Article Snippet: The full list of 388 regulated probesets was also submitted to the GeneGo Metacore tool ( http://thomsonreuters.com/products_services/science/systems-biology/ ), which comprises an integrated knowledge database and software suite for pathway analysis of gene lists.

Techniques: